Laboratoire de Louis-Charles Fortier  
Research laboratory


PUBLISHED PAPERS IN REFEREED JOURNALS (Click for a complete list in PubMed)

Underlined = students under my supervision


Characterization of Functional Prophages in Clostridium difficile.

Sekulović OFortier LC.

Methods Mol Biol. 2016;1476:143-65. doi: 10.1007/978-1-4939-6361-4_11.

PMID: 27507339

A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation.

Allard MJ, Bergeron JD, Baharnoori M, Srivastava LK, Fortier LC, Poyart C, Sébire G.

Autism Res. 2016 May 25. doi: 10.1002/aur.1647. [Epub ahead of print]

PMID: 27220806


Erratum for Boudry et al., function of the CRISPR-Cas system of the human pathogen Clostridium difficile.

Boudry P, Semenova E, Monot M, Datsenko KA, Lopatina A, Sekulovic O, Ospina-Bedoya MFortier LC, Severinov K, Dupuy B, Soutourina O.

MBio. 2015 Oct 6;6(5):e01508-15. doi: 10.1128/mBio.01508-15. No abstract available. 

PMID: 26443462 Free PMC Article

Factors Associated With Complications of Clostridium difficile Infection in a Multicenter Prospective Cohort.

Abou Chakra CN, McGeer A, Labbé AC, Simor AE, Gold WL, Muller MP, Powis J, Katz K, Garneau JRFortier LC, Pépin J, Cadarette SM, Valiquette L.

Clin Infect Dis. 2015 Dec 15;61(12):1781-8. doi: 10.1093/cid/civ749. Epub 2015 Sep 3.

PMID: 26338788

Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile.

Boudry P, Semenova E, Monot M, Datsenko KA, Lopatina A, Sekulovic O, Ospina-Bedoya MFortier LC, Severinov K, Dupuy B, Soutourina O.

MBio. 2015 Sep 1;6(5):e01112-15. doi: 10.1128/mBio.01112-15. Erratum in: MBio. 2015;6(5):e01508-15

PMID: 26330515 Free PMC Article

The Clostridium difficile cell wall protein CwpV confers phase-variable phage resistance.

Sekulovic O, Ospina Bedoya M, Fivian-Hughes AS, Fairweather NF, Fortier LC.

Mol Microbiol. 2015 Oct;98(2):329-42. doi: 10.1111/mmi.13121. Epub 2015 Aug 8.

PMID: 26179020 Free PMC Article

Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile.

Bordeleau E, Purcell EB, Lafontaine DA, Fortier LC, Tamayo R, Burrus V.

J Bacteriol. 2015 Mar;197(5):819-32. doi: 10.1128/JB.02340-14. Epub 2014 Dec 15.

PMID: 25512308 Free PMC Article

Global transcriptional response of Clostridium difficile carrying the CD38 prophage.

Sekulovic OFortier LC.

Appl Environ Microbiol. 2015 Feb;81(4):1364-74.

PMID: 25501487 Free PMC Article


Sekulovic, O, Garneau JR, Néron A, and LC Fortier. Characterization of Temperate Phages Infecting Clostridium difficile Isolates from Human and Animal Origin. Applied and Environmental Microbiology. 2014 vol. 80 (8) pp. 2555-2563

Garneau JR, Valiquette L and LC Fortier. Prevention of Clostridium difficile spore formation by sub-inhibitory concentrations of tigecycline and piperacillin/tazobactam. BMC Infectious Diseases 2014, 14:29.


Bergeron J, Deslauriers J, Grignon S, Fortier LC, Poyart C, Sébire G (2013) White matter injury and autistic-like behavior predominantly affecting male rat offspring exposed to group B streptococcal maternal inflammation. Developmental Neuroscience 12:504-515

Fortier LC* and O Sekulovic. Importance of prophages to evolution and virulence of bacterial pathogens. Invited review for Virulence 4(5):354-365 * Corresponding author.


Gebhart D, Williams S, Bishop-Lilly K, Govoni G, Willner K, Butani A, Sozhamannan S, Martin D, Fortier LC and D Scholl. Novel high-molecular-weight, R-type bacteriocins of Clostridium difficile. J Bacteriol 194:6240-6247.

Meessen-Pinard M., Sekulovic, O. and LC Fortier. Spontaneous in vivo prophage induction during Clostridium difficile infection (CDI). Appl Environ Microbiol 78:7662-7670. 


Sirard S, Valiquette L and LC Fortier. Lack of association between clinical outcome of Clostridium difficile infections, strain type, and virulence-associated phenotypes. J Clin Microbiol 49:4040-46.   

Sekulovic O. Meessen-Pinard M., and LC Fortier. Prophage-stimulated toxin production in Clostridium difficile NAP1/027 lysogens. J. Bacteriol 193: 2726-2734 

Bordeleau E., Fortier LC, Malouin F. and V. Burrus. c-di-GMP turn-over in C. difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases. PLoS Genetics, 7 (3): p. e1002039


Gonzales M., Pépin J., Frost E., Carrier J., Sirard S., Fortier LC, Lamarre P., and L. Valiquette. Faecal pharmacokinetics of orally administered vancomycin in patients with suspected Clostridium difficile infection. BMC Infect Dis, 10:363.

Mulhbacher J., Brouillette E., Allard M., Moisan H., Fortier LC, Malouin F. and DA Lafontaine. Selective Inhibitors of Guanine Riboswitches as a New Class of Antibiotics. PLoS Pathogens, 6(4): p. e1000865. 


Matte I., Lane D., Côté E., Asselin AE., Fortier LC, Asselin C. and A. Piché. Anti-apoptotic proteins Bcl-2/Bcl-XL protect human epithelial cells from Clostridium difficile toxin A-induced cell death. Infect Immun 77:5400-5410. 1

Fortier LC and S. Moineau (2009) Phage production and maintenance of stocks, including expected stock lifetimes. In M. Clokie & A. Kropinski (Eds): Methods in Molecular Biology series. Bacteriophages: Methods and Protocols. Humana Press Inc., Totowa, NJ (USA). 501:203-219.


Haaber J., Moineau S., Fortier LC, and K. Hammer. AbiV, a novel abortive phage infection mechanism on the chromosome of Lactococcus lactis subsp. cremoris MG1363 (2008) Appl Environ Microbiol. 74:6528-6537. 


Fortier LC*, and S. Moineau. (2007) Morphological and genetic diversity of temperate phages in Clostridium difficile. Appl Environ Microbiol 73(22):7358-7366 *Corresponding author. 


Fortier LC, Bransi A. and S. Moineau. (2006) Genome sequence and global gene expression of Q54, a new phage species linking the 936 and c2 phage species of Lactococcus lactis. J Bacteriol 188:6101-6114. 

Girard H., Villeneuve L., Court M. H., Fortier LC, Caron P., Hao Q., von Moltke L. L., Greenblatt D. J., and C. Guillemette. (2006) The novel UGT1A9 intronic I399 polymorphism appears as a predictor of 7-ethyl-10-hydroxycamptothecin glucuronidation levels in the liver. Drug Metab Disp 34:1220-1228.


Fortier LC, Bouchard J.D. and S. Moineau. (2005) Expression and site-directed mutagenesis of the lactococcal abortive phage infection protein AbiK. J Bacteriol. 187:3721-3730.


Girard H., Thibaudeau J., Court M.H., Fortier LC, Villeneuve L. and C. Guillemette. (2004) UGT1A1 promoter polymorphism as an important determinant of heterocyclic amine detoxification. Hepatology 42:448-457.

Girard H., Court M.H., Bernard O., Fortier LC, Villeneuve L., Hao Q., Greenblatt, D.J., vonMoltkeb L.L., Pérusse L. and C. Guillemette. (2004) Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. Pharmacogenetics 14:501-515.


Villeneuve L., Girard H., Fortier LC, and C. Guillemette. (2003) Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-Amercian subjects and their impact on the metabolism of sn-38 and flavopiridol anticancer drugs. J. Pharm Exp Ther 307:117-28.

Fortier LC, Tourdot-Maréchal R., Lee B.H., Diviès C. and J. Guzzo. (2003) Induction of Oenococcus oeni IOB84.13 H+-ATPase activity and mRNA transcription under acidic conditions of growth. FEMS Microbiol Lett 222:165-169.


Guzzo J., Coucheney F., Pierre F., Fortier LC, Delmas F., Divies C. and R. Tourdot-Maréchal. (2002) Acidophilic behaviour of the malolactic bacterium Oenococcus oeni. Sciences des Aliments - An International Journal of Food Science and Technology. 22:107-111.


Guzzo J., Jobin M-P., Delmas F., Fortier LC, Garmyn D., Tourdot-Maréchal R., Lee B.H. and C. Diviès. (2000). Regulation of stress response in Oenococcus oeni as a function of environmental changes and growth phase. Int J Food Microbiol 55:27-31.


Tourdot-Maréchal R., Fortier LC, Guzzo J., Lee B.H. et C. Diviès. (1999) Acid sensitivity of neomycin-resistant mutants of Oenococcus oeni: a relationship between reduction of ATPase activity and lack of malolactic activity. FEMS Microbiol Lett 178:319-326.


Fortier LC, Delbecchi L., Bourgaux-Ramoisy D. et P. Bourgaux. (1998). Rescue of polyomavirus DNA after co-transfection of recombinant plasmids with viral DNA fragments. Biochim Biophys Acta.  1395:96-109.